Scope and Contents

Documents on Quality Control for the HapMap Project. The documents include a revised quality guidelines statement with Working Group recommendations, a side-bar discussion on how many duplicates are needed per plate, and a short questionnaire sent out to help their initial planning phase. The documents were for the members of the Quality Control Working Group to review for their next conference call.

Scope and Contents

Correspondence and documents from the Data Flow Working Group in November 2002 that consisted of researchers, PIs, designees, funders and anyone else the seemed appropriate. This working group had a conference call on November 12/13 to discuss information flow for the first phase of the HapMap Project. Documents include a preliminary report of the conference call they all created together through e-mail.

Scope and Contents

A document for the HapMap working group titled "Considerations Relating to Interim Samples to Provide Preliminary Data for the HapMap Project." The proposal was meant to identify some interim samples that could be used for the limited purposes of SNP discovery and allele frequency estimation, but not to be genotyped as a part of the actual HapMap, raised a lot of issues. Documents also include more correspondence with the Steering Committee on sample selection.

Scope and Contents

Documents regarding obtaining more SNPs. This includes an agenda from a conference call on November 27, 2002 to discuss new SNP discovery. There is also a draft of goals for HapMap including the development of SNP assays with known allele frequencies at a high density over the entire genome. Additionally, ther is correspondence regarding Celera Sequencing IC Protocol between Arthur Holden and David Bentley from the Sanger Institute.

Scope and Contents

Documents including A proposal to The SNP Consortium titled A Haplotype Map of the Human Genome submitted by David Altshuler, David Bentley, Tom Hudson, and Eric Lander on February 15, 2002. Documents also include correspondence with Arthur Holden and David Althuler with a revised Haplotype map proposal with updated data on the distribution of blocks within and across populations and funding with other sources

Scope and Contents Documents regarding the details haplotype map project. A letter from Lynn Frampton to the HapMap Working Group Members with a status report for their search for existing samples for use in the pilot study. The list was divided into several categories, from those that seem very possible, to those not available. Documents also include notes that Leon Eisenberg sent to Francis Collins with guidelines for discussing the science and sociology of race as a basis for educating medical students on...

Scope and Contents

Documents from the Mouse Committee. This includes a document with highlights from the Trans-NIH Mouse Coordinating Committee as of December 6, 2001 and updates from the International Mouse Genome Conference in October 2001. There is also a copy of an article titled "In Silico Mapping of Complex Disease-Related Traits in Mice." Additionally, there are documents on the Drosophila Population Genomics Project.

Scope and Contents From the Series:

This series contains materials related to the International HapMap Project, including meeting files, press materials, correspondence, draft papers, and notes. The HapMap began after the completion of the Human Genome Project and ran from 2003 to 2006. It was a global effort aimed at relateing variations in the human DNA sequences with genes associated with health.

Scope and Contents Francis Collins correspondence with Gualberto Ruano, the CEO of Genaissance Pharmaceuticals. Francis attached a press release regarding Genaissance's publication in Science concerning gene haplotype analysis. Gualberto reached out to Francis Collins to address his thoughts and scientific concerns about the Genome-Wide Haplotype Map, including the purported "block" organization of LD. He believed the hypothesis appared to conflict with the facts and published results. Francis hoped to discuss...