Scope and Contents Documents on the collaboration between NHGRI and the Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT) as part of the international consortium to develop the Haplotype Map of the human genome. Documents include correspondence between Francis Collins and Dr. Satoshi Tanaka from MEXT to discuss the logistics to receive funding for the project, patent policy, and the Oversight Committee. There are multiple drafts of the offer letter that Francis Collins sent to Mr....

Scope and Contents Documents include a paper titled "Ethics and Haplotype Maps" in which the ELSI group addressed the ethic issues around creating haplotype maps of individuals from around the world. There are multiple drafts of this document with comments from ELSI staff such as Jean McEwen. Jean sent an e-mail to Francis Collins showing a lot of concern over Ellen Wright Clayton's proposal due to how premature the whole project was. Documents also include a Proposed Reconfiguration of ELSI Groups for HapMap...

Scope and Contents

Correspondence between NHGRI staff when Francis Collins decided he wanted to bring on a consultant from the private sector to help the HapMap staff manage the project for two years. Correspondence shows Arthur Holden, along with Mark Guyer, Geoff Duyk, and Bob Tepper recommending candidates along with their resumes attached. Francis Collins hoped to find someone that had previously worked in biotech.

Scope and Contents

Documents on Quality Control for the HapMap Project. The documents include a revised quality guidelines statement with Working Group recommendations, a side-bar discussion on how many duplicates are needed per plate, and a short questionnaire sent out to help their initial planning phase. The documents were for the members of the Quality Control Working Group to review for their next conference call.

Scope and Contents

Correspondence and documents from the Data Flow Working Group in November 2002 that consisted of researchers, PIs, designees, funders and anyone else the seemed appropriate. This working group had a conference call on November 12/13 to discuss information flow for the first phase of the HapMap Project. Documents include a preliminary report of the conference call they all created together through e-mail.

Scope and Contents

A document for the HapMap working group titled "Considerations Relating to Interim Samples to Provide Preliminary Data for the HapMap Project." The proposal was meant to identify some interim samples that could be used for the limited purposes of SNP discovery and allele frequency estimation, but not to be genotyped as a part of the actual HapMap, raised a lot of issues. Documents also include more correspondence with the Steering Committee on sample selection.

Scope and Contents

Documents regarding obtaining more SNPs. This includes an agenda from a conference call on November 27, 2002 to discuss new SNP discovery. There is also a draft of goals for HapMap including the development of SNP assays with known allele frequencies at a high density over the entire genome. Additionally, ther is correspondence regarding Celera Sequencing IC Protocol between Arthur Holden and David Bentley from the Sanger Institute.

Scope and Contents

Documents including A proposal to The SNP Consortium titled A Haplotype Map of the Human Genome submitted by David Altshuler, David Bentley, Tom Hudson, and Eric Lander on February 15, 2002. Documents also include correspondence with Arthur Holden and David Althuler with a revised Haplotype map proposal with updated data on the distribution of blocks within and across populations and funding with other sources

Scope and Contents Documents regarding the details haplotype map project. A letter from Lynn Frampton to the HapMap Working Group Members with a status report for their search for existing samples for use in the pilot study. The list was divided into several categories, from those that seem very possible, to those not available. Documents also include notes that Leon Eisenberg sent to Francis Collins with guidelines for discussing the science and sociology of race as a basis for educating medical students on...