Scope and Contents Kay Jaminson interviews Dr Francis Collins.  Collins talks about genetic diseases, how they run in families, look at identical twins, evidence of manic depression having a genetic basis; revolution in understanding genetic risks and diseases; consequences for discovering disease genes, short-term is availability of testing to predict risk, long-term lead to more effective therapies; manic depression common genetic disorder, maybe have a positive aspect to having the gene too; concern about...

Scope and Contents

Introduction by Francis Collins; Richard Mathies talks about technology for genome sequencing; "New Tools for Genetic Analysis"; molecular biotechnology, physical chemistry, analytical chemistry all required for for genetic sequencing; explanations of some of the new technology

Scope and Contents From the Collection:

This collection contains a large variety of media materials, including news reports, interviews with staff, press conferences, lab footage, symposia, meetings, and others. Formats include VHS, audio cassette, BetaCam, DVD, CD, and others. The majority of the materials were created during the years of the Human Genome Project (1990-2003) but also include more recent materials.

Scope and Contents

Third tape from Conference on Science of the Brain -  Starts in middle of a talk - about Alzheimer's disease, shows slides, audience questions; Dr Dennis Choi speaks about strokes, rendering brain resistant to stroke, treatments, prevention of strokes, zinc, shows slides, audience questions

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Fourth tape from Conference on Science of the Brain - Starts in middle of a talk - speech and brain injuries; close of conference

Scope and Contents

Francis Collins introduces Patrick Brown; lecture "Scanning a Genome"; genome mismatch scanning, arraying technique to look at expression of large numbers of genes at once; developing ways to tackle investigations on a whole genome scale, rather than single gene; mutant phenotypes, gene expression pattern, linkage mapping; using yeast genome

Scope and Contents

Lecture by John W. Kappler on immune response: specificity, inducibility, and memory; two types of lymphocytes: B cells and T cells; Diversity in B and T cell receptors from  combined elements; Antibodies are dimers (two pieces); Antibody monomers: light chain and heavy chain; Translation of linked genetic components into one protein; Resultant protein has specific binding surface

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Lecture by Philippa Marrack on B cells and T cells: different but complementary strategies; B cells produce antibodies that bind antigens; T cells bind antigens presented by other cells; Types of T cells: helper (CD4) and killer (CD8); Major histocompatibility complex (MHC) proteins present antigens to T cells; One T cell receptor recognizes two components: antigen plus MHC; MHC proteins vary among individuals

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Lecture by John W. Kappler on Receptor generation results in lymphocytes destructive to the host; These "self-reactive" lymphocytes are killed while immature; Those that escape may cause serious auto-immune diseases; Many factors influence onset of autoimmune diseases

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Lecture by Philippa Marrack on: many diseases can be prevented by vaccines; Pathogens' strategies to defeat the immune system: develop protective cell walls, inhibit or kill cells involved in host immune response, grow in host cells protected from antibody attack, mutate rapidly; Exploiting these strategies for better diagnoses and treatments